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- ********************************************
- * Thymidine kinase cellular-type signature *
- ********************************************
-
- Thymidine kinase (TK) (EC 2.7.1.21) is an ubiquitous enzyme that catalyzes the
- ATP-dependent phosphorylation of thymidine. A comparison of TK sequences has
- shown [1,2,3] that there are two different families of TK. One family groups
- together TK from herpesviruses as well as cellular thymidylate kinases, while
- the second family currently consists of TK from the following sources:
-
- - Vertebrates.
- - Escherichia coli.
- - Bacteriophage T4.
- - Poxviruses.
- - African swine fever virus (ASF).
- - Fish lymphocystis disease virus (FLDV).
-
- As a signature pattern for this family of TK we selected a conserved region
- which is located in the C-terminal section of these enzymes.
-
- -Consensus pattern: [GA]-x-[DE]-x-Y-x-[STAP]-x-C-[NR]-x-[CH]-[LIVMFYWH]
- -Sequences known to belong to this class detected by the pattern: ALL, except
- for TK from FLDV which is highly divergent compared to the other members of
- this family.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Note: the proteins belonging to this family also contains a copy of the ATP-
- binding motif 'A' (P-loop) in their N-terminal extremity.
-
- -Last update: October 1993 / Pattern and text revised.
-
- [ 1] Boyle D.B., Coupar B.E.H., Gibbs A.J., Seigman L.J., Both G.W.
- Virology 156:355-365(1987).
- [ 2] Blasco R., Lopez-Otin C., Munoz M., Bockamp E.-O., Simon-Mateo C.,
- Vinuela E.
- Virology 178:301-304(1990).
- [ 3] Robertson G.R., Whalley J.M.
- Nucleic Acids Res. 16:11303-11317(1988).
-